Cambridge Core - Pathology and Laboratory Science - Atlas of Gross Pathology - by Alan G. Rose. Access. PDF; Export citation. Contents. pp v-vi. Access. Detailed understanding of gross pathology is mandatory for successful patholo- gists, but this knowledge also provides a sound foundation for those intending to. Detailed understanding of gross pathology is mandatory for successful patholo- This atlas aims to provide a comprehensive illustration and description of a.
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Atlas of gross pathology with histologic correlation. Alan G Rose. Published by Cambridge University Press, New. York, , pp "Atlas of Gross Pathology With Histologic Correlation is a valuable, easy-to-use reference and review atlas, particularly for medical students, nonpathologist. This Atlas series is intended as a “first knowledge base” in the quest for placed on normal histology, gross anatomy, and gross lesion appearances since these.
Article Navigation. Close mobile search navigation Article navigation. Volume Oxford Academic. Google Scholar. Article history. Revision Received:. Cite Citation. Permissions Icon Permissions. Summary One hundred ninety-six whole human breasts were examined by a subgross sampling technique with histologic confirmation. Issue Section:. You do not currently have access to this article. Download all figures. Sign in. You could not be signed in. Sign In Forgot password? Don't have an account?
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This article is also available for rental through DeepDyve. View Metrics. Chagas disease. Myocytes contain Trypanosoma cruzi. Myocardial abscess. Myocardium contains aggregates of neutrophils. Diphtherial myocarditis. Necrosis of cardiac myocytes is more prominent than the inflammatory infiltrate.
Cardiac transplant rejection. Focal, moderate grade 2. Multifocal, moderate grade 3a. Eosinophilic myocarditis. The interstitium contains infiltrates of lymphocyte and eosinophils. Cardiomyopathy Cardiomyopathies are diseases characterized by cardiac dysfunction in which the main abnormality lies in the working myocardium. Cardiomyopathies are divided into two groups: primary idiopathic, due to unknown causes and secondary due to known causes.
Both the primary and the secondary categories have three possible functional states: 1 dilated, congestive; 2 hypertrophic, hyperdynamic; and 3 restrictive, constrictive Diagram , p.
Dilated cardiomyopathy systolic disorder is found in patients with hemochromatosis, chronic anemia, alcoholic cardiomyopathy, sarcoidosis, and many other diseases. Typically it is found in the end stages of ischemic heart disease and in hypertensive heart disease, in which it is accompanied by hypertrophy of all four cardiac chambers Fig. The dilated heart shows foci of scarring "replacement fibrosis" Fig. Thrombi tend to form in the dilated ventricle and there typically is functional mitral insufficiency.
Dilated cardiomyopathy. Ventricles and atria are dilated. There is a mural thrombus in the left ventricle.
There is replacement fibrosis in the myocardium. Diagram Specific and less specific causes of dilated, hypertrophic, and restrictive cardiomyopathy.
Hypertrophic cardiomyopathy diastolic disorder is found in patients with Friedreich ataxia, glycogen storage disease, congenital cardiomyopathies such as those related to mutations of gene for beta-myosin heavy chain, and in infants of diabetic mothers Figs. The most common cause of left ventricular hypertrophy is arterial hypertension. Cor pulmonale causes right ventricular hypertrophy.
In all these diseases there is marked hypertrophy of the cardiac myocytes, often accompanied by interstitial fibrosis. Restrictive cardiomyopathy diastolic and systolic disorder may be caused by pathologic processes involving the endocardium e. These diseases typically impede the diastolic filling of the cardiac chambers and reduce systolic ejection of blood. The pathologic changes depend on the process that has caused the disturbance, so the ventricles can be of normal size as in pericarditis or markedly thickened as in amyloidosis Figs.
Congenital hypertrophic cardiomyopathy with asymmetric septa hypertrophy. I9 Fig.
Congenital hypertrophic cardiomyopathy. Histologically the cardiac myocytes are hypertrophied and show branching and disarray. There also is considerable interstitial fibrosis. Amyloidosis of the heart. The ventricular myocardium appears thickened but pale. A, The cardiac myocytes are surrounded by hyalinized material.
B, Electron microscopy shows pericellular amyloid fibers. Narrowing or occlusion of coronary arteries typically causes myocardial ischemia, which clinically presents as angina pectoris, myocardial infarction, or chronic ischemic heart disease. Atherosclerotic plaques of coronary arteries have the same morphologic features as plaques in other sites, that is, they have an atheromatous, cholesterol-rich core surrounded by a fibrous cap Fig.
Some lesions are composed only of fibrous tissue and are calcified. Plaques may be eccentric Fig.
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